Serum Dopamine-Beta-Hydroxylase Activity

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Serum dopamine-beta-hydroxylase activity.

Dopamine-yS-liydroxylase, the enzyme which converts dopamine to norepinephrine, is released into the perfusate upon stimulation of the isolated perfused adrenal gland and after stimulation of the nerves to the isolated perfused spleen. This study was undertaken to determine whether dopamine-/?hydroxylase activity could be detected circulating in blood. By using a sensitive new enzymatic assay, ...

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Dopamine beta-hydroxylase deficiency

Dopamine beta-hydroxylase (DbetaH) deficiency is a very rare form of primary autonomic failure characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased dopamine plasma levels. The prevalence of DbetaH deficiency is unknown. Only a limited number of cases with this disease have been reported. DbetaH deficiency is mainly characterized by cardiovascular...

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A study of the possible relationship of serum dopamine-beta-hydroxylase activity with diabetic neuropathy.

Serum DBH activity in a normal population of 58 individuais shows a gaussian distribution, on the opposite to what happens in a popuiation of 100 diabetics. These two populations also differ statistically by the analysis of variance. However it was round that it is not possible to correiate ...rum DBH neither with insulin admi nistration, type of diabetes, duration of disease, nor with the seve...

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Lack of correlation between serum dopamine-beta-hydroxylase activity and blood pressure in middle-aged men.

The activity of serum dopamine-beta-hydroxylase (DBH) was measured in 1194 asymptomatic middle-aged men with diastolic blood pressure ranging from 75 to 125 mm Hg during the baseline examination of a multifactorial intervention program for primary prevention of coronary heart disease. No correlation was present between serum DBH activity and systolic (r = -0.01, NS) or diastolic (r = +0.02, NS)...

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[Experimental and clinical studies on the activity of human serum dopamine-beta-hydroxylase].

Dopamine-(9-Hydroxylase is an enzyme which catalyzes dopamine to noradrenaline in final step of catecohlamine synthesis. This study was undertaken to determine the human serum Dopaminelj3-Hydroxylase activity and examine effects of fusaric acid (5-butylpicolinic acid) on this enzyme activity in vitro and in vivo. A sensitive method for measurement of the human serum Dopamine-8-Hydroxylase activ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1971

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.28.3.307